3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol

Base Information

Chemical Name:3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol
CAS No.:784193-11-9
Molecular Formula:C₁₈H₁₂Cl₂N₄O
Molecular Weight:371.225
Hs Code.:

Synonyms:3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol

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Chemical Property of 3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol

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Technology Process of 3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol

There total 5 articles about 3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 784193-06-2
4-amino-1-(2-chlorophenyl)-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 41795-82-8
S-benzyl thioacetimidate hydrobromide

: 784193-11-9
3-(4-Chlorophenyl)-2-(2-chlorophenyl)-5-methyl-2H Pyrazolo[4,3-d]pyrimidin-7-ol

Guidance literature:: With pyridine; at 115 ℃; for 2.5h;

Reference yield:

: 876405-92-4
1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-nitroso-1H-pyrazole-3-carboxylic acid ethyl ester

: 784193-11-9
3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-methyl-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Na₂S₂O₄ / ethyl acetate

2: ethanol / Heating

With sodium dithionite; In ethanol; ethyl acetate;
DOI:10.1016/j.bmcl.2005.10.019

Reference yield:

: 99-91-2
para-chloroacetophenone

: 784193-11-9
3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-methyl-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / LiN(SiMe₃)2 / diethyl ether / -78 - 20 °C

2.1: NaNO₂ / acetic acid

2.3: H₂SO₄ / propan-2-ol

3.1: aq. Na₂S₂O₄ / ethyl acetate

4.1: ethanol / Heating

With sodium dithionite; lithium hexamethyldisilazane; sodium nitrite; In diethyl ether; ethanol; acetic acid; ethyl acetate;
DOI:10.1016/j.bmcl.2005.10.019