diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Base Information

Chemical Name:diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt
CAS No.:90913-29-4
Molecular Formula:C₇H₈O₃S*C₂₄H₂₂N₂O₅S
Molecular Weight:622.72
Hs Code.:

Synonyms:diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Suppliers and Price of diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

There total 6 articles about diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 104-15-4
toluene-4-sulfonic acid

: 90913-26-1
diphenylmethyl 7β-(tritylamino)-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate

: 90913-29-4
diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: In acetone; at 5 ℃; for 3h;
DOI:10.1021/jm00375a026

Reference yield:

: 22252-43-3,26395-99-3,70287-30-8,72059-35-9
3-deacetyloxy-7-aminocephalosporanic acid

: 90913-29-4
diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Et₃N, dimethylaniline, 2.) trimethylsilyl chloride

2: 76 percent / CH₂Cl₂ / 1 h

3: 94 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 5 °C

4: 1.) LDA / 1.) THF, hexane, HMPA, -23 deg C, 2.) THF, hexane, HMPA, -25 deg C, 3 h

5: 58 percent / acetic anhydride, trifluoroacetic anhydride, 2,6-lutidine / CH₂Cl₂ / 15 h / Ambient temperature

6: 73 percent / acetone / 3 h / 5 °C

With 2,6-dimethylpyridine; chloro-trimethyl-silane; acetic anhydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-Dimethylaniline; trifluoroacetic anhydride; lithium diisopropyl amide; In dichloromethane; acetone;
DOI:10.1021/jm00375a026

Reference yield:

: 77359-81-0
7β-(tritylamino)-3-methyl-3-cephem-4-carboxylic acid

: 90913-29-4
diphenylmethyl 7β-amino-2-<(Z)-(methoxycarbonyl)methylene>-3-methyl-3-cephem-4-carboxylate p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / CH₂Cl₂ / 1 h

2: 94 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 5 °C

3: 1.) LDA / 1.) THF, hexane, HMPA, -23 deg C, 2.) THF, hexane, HMPA, -25 deg C, 3 h

4: 58 percent / acetic anhydride, trifluoroacetic anhydride, 2,6-lutidine / CH₂Cl₂ / 15 h / Ambient temperature

5: 73 percent / acetone / 3 h / 5 °C

With 2,6-dimethylpyridine; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium diisopropyl amide; In dichloromethane; acetone;
DOI:10.1021/jm00375a026