[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

Base Information

Chemical Name:[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester
CAS No.:164083-49-2
Molecular Formula:C₂₉H₃₃N₂O₅P
Molecular Weight:520.565
Hs Code.:

Synonyms:[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

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Chemical Property of [3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

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Technology Process of [3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

There total 2 articles about [3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 177342-84-6
(3-bromopropyl)phosphonic acid dimethyl ester

: 164083-48-1
1-([1,1'-biphenyl]-2-ylmethyl)-5-hydroxy-2-methyl-1H-indole-3-acetamide

: 164083-49-2
[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

Guidance literature:: With NaH; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 164083-47-0
1-([1,1'-biphenyl]-2-ylmethyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

: 164083-49-2
[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / BBr₃ / CH₂Cl₂ / 1.25 h

2: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, 6.5 h

With boron tribromide; sodium hydride; In dichloromethane;
DOI:10.1021/jm960486n

Reference yield:

: 164083-49-2
[3-[[3-(2-amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester

: [3-[[3-(2-Amino-2-oxoethyl)-1-([1,1'-biphenyl]-2-ylmethyl)-2-methyl-1H-indol-5-yl]oxy]propyl]phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 18 h

2: MeOH / 0.5 h

With methanol; In dichloromethane;
DOI:10.1021/jm960486n