5-Methoxy-2-benzoxazolamine

Base Information

• Chemical Name: 5-Methoxy-2-benzoxazolamine
• CAS No.: 64037-14-5
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.164
• Hs Code.: 2934999090
• Mol file: 64037-14-5.mol

Synonyms:Benzoxazole,2-amino-5-methoxy- (7CI); NSC 24993

Chemical Property of 5-Methoxy-2-benzoxazolamine

Chemical Property:

• Vapor Pressure: 0.000322mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 320.2°C at 760 mmHg
• PKA: 5.12±0.10(Predicted)
• Flash Point: 147.5°C
• PSA: 61.28000
• Density: 1.304g/cm³
• LogP: 1.99980

Purity/Quality:

99% ^*data from raw suppliers

5-methoxy-1,3-benzoxazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methoxy-2-benzoxazolamine

There total 5 articles about 5-Methoxy-2-benzoxazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bromocyane (506-68-3) + 2-amino-4-methoxyphenol (20734-76-3) → 2-amino-5-methoxybenzoxazole (64037-14-5)

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.1016/j.bmcl.2016.05.017

Reference yield:

(2-hydroxy-5-methoxy-phenyl)-thiourea (500284-62-8) → 2-amino-5-methoxybenzoxazole (64037-14-5)

Guidance literature:

With lead(II) oxide; In methanol; Heating;

DOI:10.1002/jps.2600530518

Reference yield:

2-amino-4-methoxyphenol (20734-76-3) → 2-amino-5-methoxybenzoxazole (64037-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: PbO / methanol / Heating

With hydrogenchloride; lead(II) oxide; In methanol;

DOI:10.1002/jps.2600530518

upstream raw materials:

(2-hydroxy-5-methoxy-phenyl)-thiourea

bromocyane

2-amino-4-methoxyphenol

4-methoxy-2-nitrophenol

Downstream raw materials:

5-methoxy-3H-benzooxazol-2-one

Refernces