Technology Process of C19H16FNO5S
There total 10 articles about C19H16FNO5S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C20H18FNO5S;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol;
at 70 ℃;
for 1h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrogen / platinum(IV) oxide / methanol / 16 h / 20 °C
2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3.1: N-iodo-succinimide / chloroform / 16 h / 0 - 20 °C
4.1: boron tribromide / dichloromethane / 1 h / -20 °C
4.2: Cooling with ice
5.1: triethylamine / dmap / tetrahydrofuran / 3 h / 0 - 20 °C
6.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C
8.1: sodium acetate; potassium carbonate / copper dichloride; palladium dichloride / 20 °C
9.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 70 °C
9.2: 0 °C
With
piperidine; hydrogenchloride; N-iodo-succinimide; lithium hydroxide monohydrate; hydrogen; sodium acetate; boron tribromide; potassium carbonate; triethylamine;
dmap; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; copper dichloride; palladium dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.1: N-iodo-succinimide / chloroform / 16 h / 0 - 20 °C
3.1: boron tribromide / dichloromethane / 1 h / -20 °C
3.2: Cooling with ice
4.1: triethylamine / dmap / tetrahydrofuran / 3 h / 0 - 20 °C
5.1: piperidine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
6.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C
7.1: sodium acetate; potassium carbonate / copper dichloride; palladium dichloride / 20 °C
8.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 70 °C
8.2: 0 °C
With
piperidine; hydrogenchloride; N-iodo-succinimide; lithium hydroxide monohydrate; sodium acetate; boron tribromide; potassium carbonate; triethylamine;
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tri-tert-butyl phosphine; copper dichloride; palladium dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;