2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran

Base Information

• Chemical Name: 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran
• CAS No.: 1454601-05-8
• Molecular Formula: C₂₅H₂₂O₂
• Molecular Weight: 354.448
• Mol file: 1454601-05-8.mol

Synonyms:2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran

Chemical Property of 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran

There total 3 articles about 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-iododibenzo[b,d]furan-2-ol (51079-04-0) + 1-ethynyl-4-(n-pentyl)benzene (79887-10-8) → 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran (1454601-05-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.07.048

Reference yield:

C13H8O3 → 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran (1454601-05-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 2 h / 20 °C

2: acetic acid; Iodine monochloride; hydrogenchloride / water / 24 h / 20 °C

3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / Reflux; Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; acetic acid; triethylamine; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.07.048

Reference yield:

dibenzofuran-2-carbaldehyde (5397-82-0) → 2-(4-pentylphenyl)-3H-benzofuro[3,2-e]benzofuran (1454601-05-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C

2: potassium hydroxide / methanol / 2 h / 20 °C

3: acetic acid; Iodine monochloride; hydrogenchloride / water / 24 h / 20 °C

4: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / Reflux; Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Baeyer-Villiger Ketone Oxidation / 4: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.07.048

upstream raw materials:

1-iododibenzo[b,d]furan-2-ol

1-ethynyl-4-(n-pentyl)benzene

dibenzofuran-2-carbaldehyde