3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

Base Information

Chemical Name:3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine
CAS No.:151323-59-0
Molecular Formula:C₄₃H₃₆F₃N₇O
Molecular Weight:723.8
Hs Code.:

3-<(trifluoroacetyl)amino>-2-<N-propyl-N-<<2'-<2-(triphenylmethyl)-2H-tetrazol-5-yl>biphenyl-4-yl>methyl>amino>pyridine

Synonyms:3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

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Chemical Property of 3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

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Technology Process of 3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

There total 4 articles about 3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 151323-56-7
3-amino-2-biphenyl-4-yl>methyl>amino>pyridine

: 407-25-0
trifluoroacetic anhydride

: 151323-59-0
3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: With pyridine; In dichloromethane; for 1h;
DOI:10.1021/jm00070a012

Reference yield:

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 151323-59-0
3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / Ambient temperature

2: 88 percent / Et₃N / tetrahydrofuran / 2.5 h / Heating

3: 60 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 3040 Torr

4: 86 percent / pyridine / CH₂Cl₂ / 1 h

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm00070a012

Reference yield:

: 143618-24-0
Propyl-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine

: 151323-59-0
3-<(trifluoroacetyl)amino>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Et₃N / tetrahydrofuran / 2.5 h / Heating

2: 60 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 3040 Torr

3: 86 percent / pyridine / CH₂Cl₂ / 1 h

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm00070a012