Technology Process of N-benzyloxycarbonyl-6-fluoro-meta-tyramine
There total 8 articles about N-benzyloxycarbonyl-6-fluoro-meta-tyramine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(2-fluoro-5-hydroxy)phenylethyl amine;
With
triethylamine;
In
chloroform;
at 20 ℃;
for 0.166667h;
benzyl chloroformate;
In
chloroform;
at 20 ℃;
for 3h;
DOI:10.1016/S0022-1139(02)00013-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 82 percent / NaBH4 / tetrahydrofuran / 3.5 h / 20 °C
2.1: 83 percent / SO2Cl / 1 h / Heating
3.1: 95 percent / dimethylsulfoxide / 3 h / 20 °C
4.1: 52 percent / BH3 / tetrahydrofuran / 1.5 h / Heating
5.1: 95 percent / H2 / 10 percent Pd/C / ethanol
6.1: Et3N / CHCl3 / 0.17 h / 20 °C
6.2: 76 percent / CHCl3 / 3 h / 20 °C
With
sodium tetrahydroborate; sulfuryl dichloride; borane; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; chloroform; dimethyl sulfoxide;
DOI:10.1016/S0022-1139(02)00013-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 82 percent / NaBH4 / tetrahydrofuran / 3.5 h / 20 °C
2.1: 83 percent / SO2Cl / 1 h / Heating
3.1: 95 percent / dimethylsulfoxide / 3 h / 20 °C
4.1: 52 percent / BH3 / tetrahydrofuran / 1.5 h / Heating
5.1: 95 percent / H2 / 10 percent Pd/C / ethanol
6.1: Et3N / CHCl3 / 0.17 h / 20 °C
6.2: 76 percent / CHCl3 / 3 h / 20 °C
With
sodium tetrahydroborate; sulfuryl dichloride; borane; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; chloroform; dimethyl sulfoxide;
DOI:10.1016/S0022-1139(02)00013-1