GNF179 Metabolite

Base Information

• Chemical Name: GNF179 Metabolite
• CAS No.: 1310455-86-7
• Molecular Formula: C₁₄H₁₆FN₃
• Molecular Weight: 245.3
• Mol file: 1310455-86-7.mol

Synonyms:C₁₄H₁₆FN₃

Chemical Property of GNF179 Metabolite

Chemical Property:

• Boiling Point: 428.6±40.0 °C(Predicted)
• PKA: 8.43±0.40(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)

Purity/Quality:

>98% ^*data from raw suppliers

GNF179Metabolite 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GNF179 Metabolite

There total 3 articles about GNF179 Metabolite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C14H14FN3O (1261118-04-0) → C14H16FN3 (1310455-86-7)

Guidance literature:

With borane tetrahydrofuran; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1039/d0cc02728f

Reference yield:

C24H26FN3O4 (1261118-03-9) → C14H16FN3 (1310455-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 72 h / 25 °C

2: borane-THF / tetrahydrofuran / Reflux

With borane-THF; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1021/jm300041e

Reference yield:

C20H20FN3O2 (1261118-02-8) → C14H16FN3 (1310455-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 72 h / 25 °C

3: borane-THF / tetrahydrofuran / Reflux

With borane-THF; palladium on activated charcoal; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm300041e

upstream raw materials:

C₁₄H₁₄FN₃O

C₂₀H₂₀FN₃O₂

C₂₄H₂₆FN₃O₄

Downstream raw materials:

C₂₁H₂₇FN₄O₃

C₁₈H₂₁FN₆O

C₁₈H₂₃FN₄O

C₂₃H₃₁FN₄O₃

Refernces

• 1、 Nagle, Advait,Wu, Tao,Kuhen, Kelli,Gagaring, Kerstin,Borboa, Rachel,Francek, Caroline,Chen, Zhong,Plouffe, David,Lin, Xuena,Caldwell, Christopher,Ek, Jared,Skolnik, Suzanne,Liu, Fenghua,Wang, Jianling,Chang, Jonathan,Li, Chun,Liu, Bo,Hollenbeck, Thomas,Tuntland, Tove,Isbell, John,Chuan, Tiffany,Alper, Philip B.,Fischli, Christoph,Brun, Reto,Lakshminarayana, Suresh B.,Rottmann, Matthias,Diagana, Thierry T.,Winzeler, Elizabeth A.,Glynne, Richard,Tully, David C.,Chatterjee, Arnab K.. "Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents". experimental part. p. 4244 - 4273. Retrieved 2012/07/03.