6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

Base Information

Chemical Name:6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine
CAS No.:1332728-57-0
Molecular Formula:C₄₂H₄₃N₅O₈Si
Molecular Weight:773.918
Hs Code.:

Synonyms:6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

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Chemical Property of 6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

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Technology Process of 6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

There total 1 articles about 6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: benzoyloxymethoxymethyl chloride

: 77244-83-8
6-N-benzoyl-9-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

: 1332728-57-0
6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

: 1332728-59-2
6-N-benzoyl-9-(3-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

Guidance literature:: 6-N-benzoyl-9-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine; With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

benzoyloxymethoxymethyl chloride; In 1,2-dichloro-ethane; at 85 ℃; for 3h;
DOI:10.1039/c1ob05488k

Reference yield:

: 1332728-57-0
6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

: 1332728-78-5
6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranosyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; silver trifluoromethanesulfonate / 16 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1039/c1ob05488k

Reference yield:

: 1332728-57-0
6-N-benzoyl-9-(2-O-benzoyloxymethoxymethyl-5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)adenine

: 1332728-86-5
N,N-diisopropyl methyl [1-(6-N-benzoyladenine-9-yl)-2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; silver trifluoromethanesulfonate / 16 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: 1H-tetrazole / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; silver trifluoromethanesulfonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c1ob05488k