Technology Process of N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide
There total 6 articles about N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium 10% on activated carbon;
In
methanol;
Reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
2: ammonium formate / palladium 10% on activated carbon / methanol / Reflux
With
N-ethylmorpholine;; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium 10% on activated carbon;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ethanol; sodium tetrahydroborate / 6 h / 10 - 25 °C
2: boron trifluoride diethyl etherate / acetonitrile / 18 h / 25 °C / Inert atmosphere
3: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere
5: ammonium formate / palladium 10% on activated carbon / methanol / Reflux
With
N-ethylmorpholine;; sodium tetrahydroborate; ethanol; boron trifluoride diethyl etherate; water; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
