N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide

Base Information

Chemical Name:N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide
CAS No.:1297530-08-5
Molecular Formula:C₁₇H₂₀N₂O₅
Molecular Weight:332.356
Hs Code.:
Mol file:1297530-08-5.mol

Synonyms:N-(hydroxy)-2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxamide

Suppliers and Price of N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Hydroxy-2-methyl-5-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1,3-dioxane-2-carboxamide
50mg
$ 1320.00

Medical Isotopes, Inc.
N-Hydroxy-2-methyl-5-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1,3-dioxane-2-carboxamide
5 mg
$ 650.00

Total 3 raw suppliers

Chemical Property of N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Hydroxy-2-methyl-5-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1,3-dioxane-2-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-Hydroxy-2-methyl-5-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1,3-dioxane-2-carboxamide is a 1,3-dioxane derivative used as PCSK9 inhibitors and is potentially used for the treatment of dyslipidemia and related diseases.

Technology Process of N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide

There total 6 articles about N-Hydroxy-2-Methyl-5-[(5-Methyl-2-phenyl-4-oxazolyl)Methyl]-1,3-dioxane-2-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1297530-05-2
N-(benzyloxy)-2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxamide

: 1297530-08-5
N-(hydroxy)-2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; Reflux;

Reference yield:

: 1297531-31-7
2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxylic acid

: 1297530-08-5
N-(hydroxy)-2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere

2: ammonium formate / palladium 10% on activated carbon / methanol / Reflux

With N-ethylmorpholine;; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1297531-28-2
diethyl 2-((5-methyl-2-phenyloxazol-4-yl)methyl)malonate

: 1297530-08-5
N-(hydroxy)-2-methyl-5-((5-methyl-2-phenyloxazol-4-yl)methyl)-1,3-dioxane-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; sodium tetrahydroborate / 6 h / 10 - 25 °C

2: boron trifluoride diethyl etherate / acetonitrile / 18 h / 25 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere

5: ammonium formate / palladium 10% on activated carbon / methanol / Reflux

With N-ethylmorpholine;; sodium tetrahydroborate; ethanol; boron trifluoride diethyl etherate; water; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;