(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

Base Information

Chemical Name:(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone
CAS No.:1377834-33-7
Molecular Formula:C₃₂H₂₆FNO₅
Molecular Weight:523.561
Hs Code.:

Synonyms:(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

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Chemical Property of (5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

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Technology Process of (5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

There total 2 articles about (5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1395341-70-4
C₃₂H₂₈FNO₅

: 1377834-33-7
(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2012.02.036

Reference yield:

: 1377834-22-4
1-bromo-5-(4-fluorobenzyl)-2,3,4-trimethoxybenzene

: 1377834-33-7
(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / Inert atmosphere; Reflux

With tert.-butyl lithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.02.036

Reference yield: 89.0%

: 1377834-33-7
(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

: 1377834-27-9
(5-(4-fluorobenzyl)-2,3,4-trihydroxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone

Guidance literature:: (5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone; With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With water; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.02.036