2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester
• CAS No.: 82546-90-5
• Molecular Formula: C₁₇H₁₉FN₂O₄S
• Molecular Weight: 366.413
• Mol file: 82546-90-5.mol

Synonyms:2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester

Chemical Property of 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester

There total 1 articles about 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-difluoro-2-nitrobenzene (364-74-9) + ethyl 2-amino-4-isopropyl-5-methylthiophene-3-carboxylate (82546-92-7) → 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester (82546-90-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide;

DOI:10.1021/jm00352a007

Reference yield:

2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester (82546-90-5) → 2-(2-Amino-4-fluoro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester (82546-85-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 3102.9 Torr;

DOI:10.1021/jm00352a007

upstream raw materials:

1,4-difluoro-2-nitrobenzene

ethyl 2-amino-4-isopropyl-5-methylthiophene-3-carboxylate

Downstream raw materials:

2-(2-Amino-4-fluoro-phenylamino)-4-isopropyl-5-methyl-thiophene-3-carboxylic acid ethyl ester