2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene

Base Information

• Chemical Name: 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene
• CAS No.: 460087-39-2
• Molecular Formula: C₂₃H₂₃F₃O₂S
• Molecular Weight: 420.496

Synonyms:2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene

Chemical Property of 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene

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Technology Process of 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene

There total 1 articles about 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Acetyl-4-(2-hydroxy-3-tert-butyl-5-methylphenyl)benzo[b]thiophene (460087-38-1) + 2-bromo-1,1,1-trifluoroethane (421-06-7) → 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene (460087-39-2)

Guidance literature:

With caesium carbonate; In hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-(2,2-difluoro-ethoxy)-3,5-di-tert-butylphenyl)-boronic acid + 3-(1-Benzenesulfonyl-3-iodo-1H-indol-5-yl)-but-2-enoic acid methyl ester + 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene (460087-39-2) → 3-{1-Benzenesulfonyl-3-[3,5-di-tert-butyl-2-(2,2-difluro-ethoxy)-phenyl]-1H-indol-5-yl}-but-2-enoic acid methyl ester (460087-90-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In hexane; ethyl acetate; toluene;

Reference yield:

2-(2,2,2-Trifluoro-ethoxy)-3,5-di-tert-butylphenyl-boronic acid (460087-93-8) + 3-(1-Benzenesulfonyl-3-iodo-1H-indol-5-yl)-but-2-enoic acid methyl ester + 2-Acetyl-4-[2-(2,2,2-trifluoroethoxy)-3-tert-butyl-5-methylphenyl]benzo[b]thiophene (460087-39-2) → 3-{1-Benzenesulfonyl-3-[3,5-di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-1H-indol-5-yl}-but-2-enoic acid methyl ester

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;

upstream raw materials:

2-Acetyl-4-(2-hydroxy-3-tert-butyl-5-methylphenyl)benzo[b]thiophene

2-bromo-1,1,1-trifluoroethane

Downstream raw materials:

3-{1-Benzenesulfonyl-3-[3,5-di-tert-butyl-2-(2,2-difluro-ethoxy)-phenyl]-1H-indol-5-yl}-but-2-enoic acid methyl ester

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