(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

Base Information

Chemical Name:(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone
CAS No.:67287-75-6
Molecular Formula:C₂₃H₂₂ClNO₄
Molecular Weight:411.885
Hs Code.:

Synonyms:(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

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Chemical Property of (6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

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Technology Process of (6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

There total 3 articles about (6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67287-38-1
6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 80751-52-6
2-furoyl N-hydroxysuccinimide ester

: 67287-75-6
(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

Guidance literature:: With sodium hydrogencarbonate; In 2-methoxy-ethanol; water; at 25 ℃; for 4h;
DOI:10.1021/jm00346a005

Reference yield:

: 88-14-2
2-furanoic acid

: 67287-75-6
(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran

2: NaHCO₃ / H₂O; 2-methoxy-ethanol / 4 h / 25 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 2-methoxy-ethanol; water;
DOI:10.1021/jm00346a005

Reference yield:

: 67287-37-0
N-(2-Hydroxy-2-phenethyl)-N-<2-(2'-chlor-3',4'-dimethoxyphenyl)-ethyl>-amin

: 67287-75-6
(6-Chloro-7,8-dimethoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄, CF₃COOH / 2 h / Heating

2: NaHCO₃ / H₂O; 2-methoxy-ethanol / 4 h / 25 °C

With sulfuric acid; sodium hydrogencarbonate; trifluoroacetic acid; In 2-methoxy-ethanol; water;
DOI:10.1021/jm00346a005