3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one

Base Information

• Chemical Name: 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one
• CAS No.: 51146-98-6
• Molecular Formula: C₁₃H₁₂Cl₂N₂O₆
• Molecular Weight: 363.154
• Mol file: 51146-98-6.mol

Synonyms:3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one

Chemical Property of 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one

There total 3 articles about 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloramphenicol (26367-75-9) + acetic anhydride (108-24-7) → 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one (51146-98-6)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01145a523

Reference yield:

dichloro-acetic acid-(4-nitro-phenacylamide) (91687-43-3) → 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one (51146-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃; aqueous ethanol

2: H₂SO₄

With ethanol; sulfuric acid; sodium hydrogencarbonate;

DOI:10.1021/ja01145a523

Reference yield:

2-amino-1-(4-nitro-phenyl)-ethanone (4740-22-1) → 3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-one (51146-98-6)

Guidance literature:

Multi-step reaction with 3 steps

2: NaHCO₃; aqueous ethanol

3: H₂SO₄

With ethanol; sulfuric acid; sodium hydrogencarbonate;

DOI:10.1021/ja01145a523

upstream raw materials:

chloramphenicol

acetic anhydride

dichloro-acetic acid-(4-nitro-phenacylamide)

2-amino-1-(4-nitro-phenyl)-ethanone

Downstream raw materials:

(1RS,2SR)-2-amino-1-(4-nitro-phenyl)-propane-1,3-diol

(1RS,2SR)-3-acetoxy-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propan-1-ol

2-(2,2-dichloroacetylamino)-1-(4-nitrophenyl)propane-1,3-diol