cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Base Information

Chemical Name:cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester
CAS No.:647013-47-6
Molecular Formula:C₂₃H₂₇NO₆
Molecular Weight:413.47
Hs Code.:

Synonyms:cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Suppliers and Price of cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

There total 6 articles about cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 647013-46-5
3-(2,6-dimethyl-phenyl)-4-hydroxy-1-methoxymethoxy-1-aza-spiro[4.5]dec-3-ene-2,8-dione

: 647013-47-6
cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 647013-47-6
cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1-chloro-1-nitrosocyclohexane / tetrahydrofuran; hexane / 1 h / -40 °C

1.3: 72 percent / aq. HCl / tetrahydrofuran; hexane / 3 h / 20 °C

2.1: 33 percent / aq. NaHCO₃ / ethyl acetate / 3 h / 0 - 20 °C

3.1: 83 percent / aq. HCl / tetrahydrofuran / 1.5 h / 60 °C

4.1: NaH / dimethylformamide / 3 h / 0 - 20 °C

5.1: t-BuOK / dimethylformamide / 2 h / 20 °C

6.1: Et₃N / tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; sodium hydride; sodium hydrogencarbonate; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 647013-28-3
ethyl 8-hydroxyamino-1,4-dioxaspiro[4,5]decane-8-carboxylate

: 647013-47-6
cyclopropanecarboxylic acid 3-(2,6-dimethyl-phenyl)-1-methoxymethoxy-2,8-dioxo-1-aza-spiro[4.5]dec-3-en-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 33 percent / aq. NaHCO₃ / ethyl acetate / 3 h / 0 - 20 °C

2: 83 percent / aq. HCl / tetrahydrofuran / 1.5 h / 60 °C

3: NaH / dimethylformamide / 3 h / 0 - 20 °C

4: t-BuOK / dimethylformamide / 2 h / 20 °C

5: Et₃N / tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; potassium tert-butylate; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;