(2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Name:(2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:73707-60-5
Molecular Formula:C₂₂H₂₃N₃O₅S₂
Molecular Weight:473.574
Hs Code.:

Synonyms:(2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

There total 2 articles about (2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.5%

: 87680-41-9
C₂₂H₂₁N₃O₅S₂

: 73707-60-5
(2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: With triphenylphosphine; In dichloromethane;
DOI:10.1021/ja00525a038

Reference yield:

: 81658-72-2
p-nitrobenzyl 6β-aminopenicillanate p-toluenosulfonic acid salt

: 73707-60-5
(2S,5R,6S)-6-Amino-3,3-dimethyl-7-oxo-6-p-tolylsulfanyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / triethylamine, propylene oxide / CH₂Cl₂ / molecular sieves

2: 59.5 percent / triphenylphosphine / CH₂Cl₂

With triethylamine; triphenylphosphine; methyloxirane; In dichloromethane;
DOI:10.1021/ja00525a038