4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

Base Information

Chemical Name:4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride
CAS No.:1202462-54-1
Molecular Formula:C₁₂H₂₀F₃NO*ClH
Molecular Weight:287.753
Hs Code.:

Synonyms:4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

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Chemical Property of 4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

Chemical Property:

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Technology Process of 4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

There total 5 articles about 4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₈F₃NO₂S

: 1202462-54-1
4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 - 50 ℃;

Reference yield:

: 916159-85-8
8-(cyclopropylmethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

: 1202462-54-1
4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diisobutylaluminium hydride / toluene / -78 - 0 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 21 h / 20 °C / Reflux

3.1: tetramethylammonium fluoride / tetrahydrofuran / -40 - 0 °C

4.1: acetic acid / 0.17 h / 130 °C / Microwave irradiation

4.2: 0.5 h / 20 °C

5.1: sodium tetrahydroborate / ethanol / 0 °C

6.1: hydrogenchloride / water; isopropyl alcohol / 20 - 50 °C

With tetrahydrofuran; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; tetramethylammonium fluoride; diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;

Reference yield:

: 1202462-83-6
8-cyclopropylmethyl-1,4-dioxa-spiro[4.5]decane-8-carbaldehyde

: 1202462-54-1
4-(1-amino-2,2,2-trifluoro-ethyl)-4-cyclopropylmethyl-cyclohexanol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 21 h / 20 °C / Reflux

2.1: tetramethylammonium fluoride / tetrahydrofuran / -40 - 0 °C

3.1: acetic acid / 0.17 h / 130 °C / Microwave irradiation

3.2: 0.5 h / 20 °C

4.1: sodium tetrahydroborate / ethanol / 0 °C

5.1: hydrogenchloride / water; isopropyl alcohol / 20 - 50 °C

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; tetramethylammonium fluoride; acetic acid; In tetrahydrofuran; ethanol; water; isopropyl alcohol;