4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

Base Information

Chemical Name:4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline
CAS No.:1136832-80-8
Molecular Formula:C₂₁H₁₄F₃N₃O₂
Molecular Weight:397.356
Hs Code.:

Synonyms:4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

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Chemical Property of 4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

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Technology Process of 4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

There total 5 articles about 4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1136832-79-5
3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-5-(4-nitrophenyl-1,2,4-oxadiazole)

: 1136832-80-8
4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

Guidance literature:: With hydrogenchloride; water; iron; In ethanol; at 95 ℃; for 1h;

Reference yield:

: 3058-39-7
4-iodobenzonitrile

: 1136832-80-8
4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) iodide / 1,4-dioxane / 140 h / 90 °C / Inert atmosphere

2: hydroxylamine / ethanol / 1 h / Reflux

3: toluene / 5.5 h / Reflux

4: iron; hydrogenchloride / ethanol; water / 1 h / 95 °C

With hydrogenchloride; copper(l) iodide; hydroxylamine; N,N-dimethylglycine hydrochoride; iron; caesium carbonate; In 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/ja500053x

Reference yield:

: 860004-31-5
4-(4-(trifluoromethyl)phenoxy)benzonitrile

: 1136832-80-8
4-(3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazol-5-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine / ethanol / 1 h / Reflux

2: toluene / 5.5 h / Reflux

3: iron; hydrogenchloride / ethanol; water / 1 h / 95 °C

With hydrogenchloride; hydroxylamine; iron; In ethanol; water; toluene;
DOI:10.1021/ja500053x