Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester
CAS No.:130114-63-5
Molecular Formula:C₂₀H₂₂O₆
Molecular Weight:358.391
Hs Code.:

Synonyms:Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

There total 6 articles about Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 130114-67-9
(3aS,4S,6aS)-4-Benzyloxymethyl-4-methoxy-tetrahydro-furo[3,4-d][1,3,2]dioxathiole 2,2-dioxide

: 1863-63-4,21292-26-2,28271-83-2,143502-10-7
ammonium benzoate

: 130114-63-5
Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 24h;
DOI:10.1016/0040-4039(90)80222-8

Reference yield:

: 2042-27-5
L-ribulose

: 130114-63-5
Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / pTSA / 24 h / Ambient temperature

2: 92 percent / KOtBu / tetrahydrofuran / 2 h / Ambient temperature

3: 1) 80percent AcOH, 2) 28percent NH₄OH / 1) r.t., 10 min, 2) r.t., 15 min

4: 1) SOCl₂, NEt₃, 2) RuCl₃*3H₂O, NaIO₄ / 1) CCl₄, 0 deg C, 10 min, 2) CCl₄, MeCN, H₂O, 0 deg C, 60 min

5: 70 percent / dimethylformamide / 24 h / 80 °C

With ruthenium trichloride; ammonium hydroxide; sodium periodate; thionyl chloride; potassium tert-butylate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(90)80222-8

Reference yield:

: 130114-49-7,130114-50-0
((3aS,4S,6aS)-2,4-Dimethoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-methanol

: 130114-63-5
Benzoic acid (3R,4S,5S)-5-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / KOtBu / tetrahydrofuran / 2 h / Ambient temperature

2: 1) 80percent AcOH, 2) 28percent NH₄OH / 1) r.t., 10 min, 2) r.t., 15 min

3: 1) SOCl₂, NEt₃, 2) RuCl₃*3H₂O, NaIO₄ / 1) CCl₄, 0 deg C, 10 min, 2) CCl₄, MeCN, H₂O, 0 deg C, 60 min

4: 70 percent / dimethylformamide / 24 h / 80 °C

With ruthenium trichloride; ammonium hydroxide; sodium periodate; thionyl chloride; potassium tert-butylate; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(90)80222-8