2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

Base Information

Chemical Name:2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone
CAS No.:134136-74-6
Molecular Formula:C₃₀H₄₅NO₃Si
Molecular Weight:495.778
Hs Code.:

Synonyms:2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

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Chemical Property of 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

Chemical Property:

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Technology Process of 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

There total 4 articles about 2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51135-96-7
4-benzyl-4-hydroxypiperidine

: 134136-66-6
4-(triisopropylsilyloxy)-alpha-bromopropiophenone

: 134136-74-6
2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

Guidance literature:: With triethylamine; In ethanol; for 16h; Heating;
DOI:10.1021/jm00016a017

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 134136-74-6
2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / imidazole / dimethylformamide / 3 h

2: 100 percent / Br₂ / CCl₄ / 1.5 h

3: Et₃N / ethanol / 16 h / Heating

With 1H-imidazole; bromine; triethylamine; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00016a017

Reference yield:

: 134136-88-2
1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one

: 134136-74-6
2-(4-Benzyl-4-hydroxypiperidino)-1-(4-(triisopropylsilyloxy)phenyl)-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Br₂ / CCl₄ / 1.5 h

2: Et₃N / ethanol / 16 h / Heating

With bromine; triethylamine; In tetrachloromethane; ethanol;
DOI:10.1021/jm00016a017