2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

Base Information

Chemical Name:2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile
CAS No.:1584731-76-9
Molecular Formula:C₂₈H₃₄Cl₂N₂O₃S
Molecular Weight:549.562
Hs Code.:

Synonyms:2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

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Chemical Property of 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

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Technology Process of 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

There total 3 articles about 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1584731-40-7
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetamide

: 1584731-76-9
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm401911v

Reference yield:

: C₂₈H₃₄Cl₃NO₄S

: 1584731-76-9
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / water / 3 h / 0 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With ammonia; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; water;
DOI:10.1021/jm401911v

Reference yield:

: 1352066-48-8
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1584731-76-9
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: ammonia / water / 3 h / 0 °C / Inert atmosphere

3: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; ammonia; triethylamine; trifluoroacetic anhydride; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1021/jm401911v