Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

Base Information

Chemical Name:Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate
CAS No.:136006-59-2
Molecular Formula:C₁₉H₂₂Cl₂FO₅*Na
Molecular Weight:443.275
Hs Code.:

Synonyms:Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

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Chemical Property of Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

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Technology Process of Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

There total 12 articles about Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136006-75-2
(4R,6S)-6-[2,4-Dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxymethyl]-4-hydroxy-tetrahydro-pyran-2-one

: 136006-59-2
Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

Guidance literature:: With sodium hydroxide; In ethanol; at 20 - 25 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: 110772-23-1
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 136006-59-2
Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 90 percent / NaI / acetone / 24 h / Heating

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

6: 84 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

7: 1N NaOH / ethanol / 1 h / 20 - 25 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; Celite; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; hydroquinone; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00114a004

Reference yield:

: Cyclohexanecarboxylic acid 2,4-dichloro-phenyl ester

: 136006-59-2
Sodium; (3R,5S)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxy]-3,5-dihydroxy-hexanoate

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / 4 h / 150 °C

2: 47 percent / Et₂NSF₃ / toluene / 2 h / 25 °C

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

6: 84 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

7: 1N NaOH / ethanol / 1 h / 20 - 25 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; aluminium trichloride; diethylamino-sulfur trifluoride; Celite; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; hydroquinone; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00114a004