tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate
• CAS No.: 1018910-23-0
• Molecular Formula: C₃₆H₅₃FN₄O₇
• Molecular Weight: 672.838

Synonyms:tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

Chemical Property of tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

There total 2 articles about tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

tert-butyl (3S,4R)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate (1018910-22-9) → tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate (1018910-23-0)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In ethanol; at 60 ℃; for 36h;

DOI:10.1021/jm100947x

Reference yield: 48.0%

→ tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate (1018910-23-0)

Guidance literature:

Reference yield: 100.0%

tert-butyl (3R,4S)-3-(6-tert-butoxycarbonylamino-4-methyl-pyridin-2-ylmethyl)-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate (1018910-23-0) → 6-((3S,4R)-4-{2-[2-(3-fluoro-phenyl)-ethylamino]-ethoxy}-pyrrolidin-3-ylmethyl)-4-methyl-pyridin-2-ylamine trihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 37h; Cooling with ice; Inert atmosphere;

DOI:10.1021/jm100947x

upstream raw materials:

tert-butyl (3S,4R)-3-[6-(benzyl-tert-butoxycarbonyl-amino)-4-methyl-pyridin-2-ylmethyl]-4-(2-{tert-butoxycarbonyl-[2-(3-fluoro-phenyl)-ethyl]-amino}-ethoxy)-pyrrolidine-1-carboxylate

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