5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Base Information

Chemical Name:5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine
CAS No.:1011476-64-4
Molecular Formula:C₂₃H₂₇N₃OS
Molecular Weight:393.553
Hs Code.:

Synonyms:5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

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Chemical Property of 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

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Technology Process of 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

There total 6 articles about 5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011476-62-2
6-isobutyl-5-methyl-nicotinic acid N'-(4-allyloxy-3,5-dimethyl-benzoyl)-hydrazide

: 1011476-64-4
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 110 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 1011476-39-3
5-methyl-6-(2-methylpropenyl)nicotinic acid ethyl ester

: 1011476-64-4
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 15 h / 20 °C / 760.05 Torr

2: hydrogenchloride; water / 24 h / 65 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 16 h / 0 °C

4: Lawessons reagent / tetrahydrofuran / 0.08 h / 110 °C / Microwave

With Lawessons reagent; hydrogenchloride; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1011476-40-6
6-isobutyl-5-methylnicotinic acid ethyl ester

: 1011476-64-4
5-[5-(4-allyloxy-3,5-dimethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-2-isobutyl-3-methyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 24 h / 65 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 - 16 h / 0 °C

3: Lawessons reagent / tetrahydrofuran / 0.08 h / 110 °C / Microwave

With Lawessons reagent; hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;