1-azido-3,5-di-tert-butylbenzene

Base Information

• Chemical Name: 1-azido-3,5-di-tert-butylbenzene
• CAS No.: 1275593-72-0
• Molecular Formula: C₁₄H₂₁N₃
• Molecular Weight: 231.341
• Mol file: 1275593-72-0.mol

Synonyms:1-azido-3,5-di-tert-butylbenzene

Chemical Property of 1-azido-3,5-di-tert-butylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-azido-3,5-di-tert-butylbenzene

There total 2 articles about 1-azido-3,5-di-tert-butylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-bromo-3,5-di-tert-butylbenzene (22385-77-9) → 1-azido-3,5-di-tert-butylbenzene (1275593-72-0)

Guidance literature:

With copper(l) iodide; sodium azide; L-proline; sodium hydroxide; In ethanol; water; at 95 ℃; for 23h; Sealed tube;

DOI:10.1016/j.bmcl.2017.01.092

Reference yield: 41.0%

3,5-di-tert-butylaniline (2380-36-1) → 1-azido-3,5-di-tert-butylbenzene (1275593-72-0)

Guidance literature:

3,5-di-tert-butylaniline; With trifluoroacetic acid; sodium nitrite; at -10 ℃; for 0.75h;

With sodium azide; at -10 ℃; for 2.08333h;

DOI:10.1039/c0jm03117h

Reference yield: 99.0%

1,3-di-tert-butyl-5-ethynylbenzene (36720-94-2) + 1-azido-3,5-di-tert-butylbenzene (1275593-72-0) + C30H30N2O4 (1309386-19-3) → 1,4-bis(3,5-di-tert-butylphenyl)-1H-1,2,3-triazole (1309386-33-1) + C30H30N2O4*C30H43N3 (1309386-34-2)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; In dichloromethane; at 80 ℃; for 72h; Inert atmosphere;

DOI:10.1002/anie.201100415

upstream raw materials:

3,5-di-tert-butylaniline

1-bromo-3,5-di-tert-butylbenzene

Downstream raw materials:

C₂₆H₃₄IN₃

C₂₆H₃₄IN₃*C₃₀H₃₀N₂O₄

1,4-bis(3,5-di-tert-butylphenyl)-1H-1,2,3-triazole

C₃₀H₃₀N₂O₄*C₃₀H₄₃N₃

Refernces

• 1、 Pryjomska-Ray, Iweta,Zornik, Denise,P?tzel, Michael,Krause, Konstantin B.,Grubert, Lutz,Braun-Cula, Beatrice,Hecht, Stefan,Limberg, Christian. "Comparing Isomeric Tridentate Carbazole-Based Click Ligands: Metal Complexes and Redox Chemistry". . p. 5341 - 5349. Retrieved 2018.
• 2、 Juriek, Michal,Felici, Marco,Contreras-Carballada, Pablo,Lauko, Jan,Bou, Sandra Rodriguez,Kouwer, Paul H. J.,Brouwer, Albert M.,Rowan, Alan E.. "Triazole-pyridine ligands: A novel approach to chromophoric iridium arrays". supporting information; experimental part. p. 2104 - 2111. Retrieved 2011/10/02.