6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

Base Information

Chemical Name:6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile
CAS No.:1441049-30-4
Molecular Formula:C₂₀H₁₅F₃N₂O₂
Molecular Weight:372.347
Hs Code.:

Synonyms:6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

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Chemical Property of 6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

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Technology Process of 6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

There total 6 articles about 6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6-(4-bromophenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

: 1441049-30-4
6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; water; at 140 ℃; for 0.25h; Microwave irradiation; Inert atmosphere;

Reference yield: 85.0%

: 6-(4-bromophenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridine-3-carbonitrile

: 1441049-30-4
6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; water; at 140 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acs.jmedchem.1c01356

Reference yield:

: 619-41-0
4-(bromoacetyl)toluene

: 1441049-30-4
6-(4-hydroxyphenyl)-2-oxo-4-p-tolyl-6-(trifluoromethyl)-1,2,5,6-tetrahydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

1.2: 16 h / 20 °C

2.1: tetrahydrofuran / 150 °C / Microwave irradiation

3.1: ammonium hydroxide / dimethyl sulfoxide / 48 h / 20 °C / Sealed tube

4.1: pyridine; dmap / dichloromethane / 2.83 h / 0 - 20 °C

5.1: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / water; 1,4-dioxane / 0.25 h / 140 °C / Microwave irradiation; Inert atmosphere

With pyridine; dmap; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;