tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

Base Information

Chemical Name:tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate
CAS No.:1313216-89-5
Molecular Formula:C₃₅H₄₆N₄O₆S
Molecular Weight:650.839
Hs Code.:

Synonyms:tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

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Chemical Property of tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

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Technology Process of tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

There total 9 articles about tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 109-72-8,29786-93-4
n-butyllithium

: 1313216-88-4
tert-butyl ({6-[(4-acetylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-yl}tert-butoxycarbonylamino)acetate

: 1313216-89-5
tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: n-butyllithium; With n-butyl(triphenyl)phosphonium bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

tert-butyl ({6-[(4-acetylbenzyl)(pyridin-2-ylsulfonyl)aminomethyl]pyridin-2-yl}tert-butoxycarbonylamino)acetate; In tetrahydrofuran; hexane; at 20 ℃; for 16h; Reflux;

Reference yield:

: 66715-65-9
pyridine-2-sulfonyl chloride

: 1313216-89-5
tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

2.1: tributylphosphine; diamide / tetrahydrofuran / 13 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide; -butyl vinyl ether / 20 h / 100 - 120 °C

3.2: 4 h / 20 °C

4.1: n-butyl(triphenyl)phosphonium bromide / hexane; tetrahydrofuran / 1 h / -78 - 20 °C

4.2: 16 h / 20 °C / Reflux

With tributylphosphine; diamide; n-butyl(triphenyl)phosphonium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; -butyl vinyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1313216-89-5
tert-butyl [tert-butoxycarbonyl(6-{[4-(1-methyl-1-pentenyl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: calcium chloride; potassium borohydride / Tetraethylene glycol dimethyl ether; ethanol / 0.92 h / 20 - 35 °C / Cooling with ice

2.2: 1.17 h / 20 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 13 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide; -butyl vinyl ether / 20 h / 100 - 120 °C

4.2: 4 h / 20 °C

5.1: n-butyl(triphenyl)phosphonium bromide / hexane; tetrahydrofuran / 1 h / -78 - 20 °C

5.2: 16 h / 20 °C / Reflux

With potassium borohydride; tributylphosphine; diamide; n-butyl(triphenyl)phosphonium bromide; sodium hydride; N-ethyl-N,N-diisopropylamine; calcium chloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; -butyl vinyl ether; ethanol; hexane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil; 3.1: Mitsunobu reaction;