[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

Base Information

Chemical Name:[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate
CAS No.:246510-15-6
Molecular Formula:C₄₂H₄₈O₄Si
Molecular Weight:644.926
Hs Code.:

Synonyms:[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

Chemical Property:

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Technology Process of [2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

There total 1 articles about [2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 76-83-5
trityl chloride

: 139278-28-7
(S)-1-(2-naphthyl)ethyl (3S)-5-hydroxy-3-(tert-butyldimethylsiloxy)pentanoate

: 246510-15-6
[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(99)00438-X

Reference yield: 89.0%

: 246510-15-6
[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

: 203454-35-7
(3S)-3-(tert-butyldimethylsiloxy)-5-triphenylmethyloxypentanal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;
DOI:10.1016/S0040-4020(99)00438-X

Reference yield:

: 246510-15-6
[2'S,3S]-1-(2'-naphthyl)ethyl 3-(tert-butyldimethylsiloxy)-5-triphenyl-methyloxy-pentanoate

: 203454-41-5
[2S,4S,6S]-4-(N-methoxy-N-methyl-carboxamidomethyl)-6-[(2-triphenylmethyloxy)-ethyl]-2-phenyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / DIBAlH / toluene / 2 h / -78 °C

2: 94 percent / CH₂Cl₂ / 12 h / 20 °C

3: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

4: 83 percent / t-BuOK / tetrahydrofuran / 0.42 h / 0 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene; 1: Reduction / 2: Condensation / 3: Substitution / 4: Addition;
DOI:10.1016/S0040-4020(99)00438-X