N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Base Information

Chemical Name:N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine
CAS No.:1401348-36-4
Molecular Formula:C₃₅H₃₅N₇O₄S
Molecular Weight:649.773
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

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Chemical Property of N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

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Technology Process of N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

There total 8 articles about N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.1%

: 1401350-33-1
2-(2-methylpiperidin-1-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine

: 1401348-35-3
5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine

: 1401348-36-4
N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: With potassium phosphate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 0.166667h; microwave irradiation; Inert atmosphere; Sealed tube;

Reference yield:

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 1401348-36-4
N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 65 - 80 °C

2: hydrazine / ethanol / 12 h / Reflux

3: ethanol / 2 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux

5: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C

7: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 120 °C / microwave irradiation; Inert atmosphere; Sealed tube

With potassium phosphate; iodine; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; hydrazine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 3694-57-3
1-(isothiocyanatomethyl)-4-methoxybenzene

: 1401348-36-4
N-(4-methoxybenzyl)-5-(3-(6-(2-methylpiperidin-1-yl)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux

3: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C

5: potassium phosphate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 120 °C / microwave irradiation; Inert atmosphere; Sealed tube

With potassium phosphate; iodine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;