1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

Base Information

Chemical Name:1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine
CAS No.:1275578-39-6
Molecular Formula:C₂₁H₂₄ClN₅
Molecular Weight:381.908
Hs Code.:

Synonyms:1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

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Chemical Property of 1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

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Technology Process of 1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

There total 3 articles about 1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 288-88-0
1,2,4-Triazole

: 102163-64-4
1-(2-chloroethyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine

: 1275578-39-6
1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

Guidance literature:: 1,2,4-Triazole; With potassium carbonate; In acetonitrile; at 45 ℃; for 1h;

1-(2-chloroethyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine; In acetonitrile; at 20 - 70 ℃;
DOI:10.5012/bkcs.2010.31.12.3684

Reference yield:

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 1275578-39-6
1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 1 h / 45 °C

2.2: 20 - 70 °C

With potassium carbonate; triethylamine; In acetonitrile;
DOI:10.5012/bkcs.2010.31.12.3684

Reference yield:

: 109806-71-5
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

: 1275578-39-6
1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / 16 h / Reflux

2: tetraethylammonium iodide; potassium carbonate; sodium hydroxide / acetonitrile / 24 h / Reflux

With pyridine; thionyl chloride; tetraethylammonium iodide; potassium carbonate; sodium hydroxide; In acetonitrile;
DOI:10.1002/ardp.201000357