N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Base Information

Chemical Name:N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide
CAS No.:690695-16-0
Molecular Formula:C₁₆H₁₀ClNO₃
Molecular Weight:299.713
Hs Code.:
DSSTox Substance ID:DTXSID201324578
Nikkaji Number:J3.023.074D
ChEMBL ID:CHEMBL1507209

Synonyms:N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide;690695-16-0;N-(2-chlorophenyl)-4-oxochromene-2-carboxamide;MLS001164470;CHEMBL1507209;DTXSID201324578;HMS2844F06;HMS3448P06;STK925972;AKOS001043090;CCG-146174;WAY-632557;NCGC00315358-01;SMR000497444;AB00820745-06;SR-01000253596;SR-01000253596-1;Z27812334

Suppliers and Price of N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:299.0349209
Heavy Atom Count:21
Complexity:462

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)C=C(O2)C(=O)NC3=CC=CC=C3Cl

Technology Process of N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

There total 3 articles about N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5112-47-0
4-oxo-4H-chromene-2-carbonyl chloride

: 95-51-2
o-chloroaniline

: 690695-16-0
N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 160 ℃; for 0.0833333h; Microwave irradiation;
DOI:10.1016/j.tetlet.2011.09.095

Reference yield: 23.0%

: 4940-39-0
acide chromone carboxylique-2

: 95-51-2
o-chloroaniline

: 690695-16-0
N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,1,1-trichloroethane; at 20 ℃; for 4.5h; Cooling with ice;
DOI:10.1016/j.tetlet.2011.09.095

Reference yield:

: 4940-39-0
acide chromone carboxylique-2

: 690695-16-0
N-(2-chlorophenyl)-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave irradiation

With trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.09.095