8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Base Information

Chemical Name:8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine
CAS No.:1379508-89-0
Molecular Formula:C₂₀H₁₉N₅O₂
Molecular Weight:361.403
Hs Code.:

8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N<sup>9</sup>-propargyladenine

Synonyms:8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Suppliers and Price of 8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

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Technology Process of 8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

There total 7 articles about 8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 13331-23-2
fur-2-ylboronic acid

: 1379508-88-9
8-bromo-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

: 1379508-89-0
8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.416667h;
DOI:10.1016/j.bmc.2014.04.041

Reference yield:

: 1379508-87-8
2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]adenine

: 1379508-89-0
8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h

2.2: 4.5 h

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.42 h / 100 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 141345-32-6
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-<2-(1-hydroxycyclohexyl)-1-ethyn-1-yl>purine

: 1379508-89-0
8-(2-furyl)-2-[2-(1-hydroxycyclohexyl)-1-ethyn-1-yl]-N⁹-propargyladenine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / 1,4-dioxane; water / 22 h / 70 °C / Sealed tube

2.1: hydrogenchloride / 1,4-dioxane; water / 5.5 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h

4.2: 4.5 h

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.42 h / 100 °C

With hydrogenchloride; ammonium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;