Technology Process of (2R,3R,4R)-2,4-dimethyl-5-(phenylthio)pentane-1,3-diol
There total 8 articles about (2R,3R,4R)-2,4-dimethyl-5-(phenylthio)pentane-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3R,4R)-3-hydroxy-5-iodo-2,4-dimethylpentyl acetate; thiophenol;
With
sodium;
In
ethanol;
at 20 ℃;
for 5h;
Inert atmosphere;
Cooling with ice;
With
ethanol; potassium carbonate;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1246/bcsj.20140271
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 68 percent / tetrahydrofuran / 144 h / Ambient temperature; Pseudomonas fluorescens
2: 1.) tosyl chloride, pyridine, 2.) NaI, 3.) K2CO3 / 1.) 4 deg C, 16 h, 2.) acetone, RT, 4 h, 3.) EtOH, RT, 5 h, then RT, 1 h
With
pyridine; potassium carbonate; p-toluenesulfonyl chloride; sodium iodide;
In
tetrahydrofuran;
DOI:10.1016/0040-4039(96)00417-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) CH2N2, 2.) LAH / 1.) ether, 2.) THF, RT, 3 h
2: 68 percent / tetrahydrofuran / 144 h / Ambient temperature; Pseudomonas fluorescens
3: 1.) tosyl chloride, pyridine, 2.) NaI, 3.) K2CO3 / 1.) 4 deg C, 16 h, 2.) acetone, RT, 4 h, 3.) EtOH, RT, 5 h, then RT, 1 h
With
diazomethane; pyridine; lithium aluminium tetrahydride; potassium carbonate; p-toluenesulfonyl chloride; sodium iodide;
In
tetrahydrofuran;
DOI:10.1016/0040-4039(96)00417-0
