Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate

Base Information

Chemical Name:Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate
CAS No.:327969-65-3
Molecular Formula:C16H24O4S
Molecular Weight:312.4244
Hs Code.:
DSSTox Substance ID:DTXSID60954459
Nikkaji Number:J1.279.905E

Synonyms:CCRIS 8744;327969-65-3;Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate;Oxirane-2-carboxylic acid, 2-(6-(thienylmethoxy)hexyl)-, ethyl ester, (2R)-;ETHYL (2R)-2-[6-(THIENYLMETHOXY)HEXYL]OXIRANE-2-CARBOXYLATE;DTXSID60954459;2-[6-(2-Thienylmethoxy)hexyl]oxirane-2-carboxylic acid ethyl ester;Ethyl 2-{6-[(thiophen-2-yl)methoxy]hexyl}oxirane-2-carboxylate

Suppliers and Price of Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate

Chemical Property:

Vapor Pressure:4.54E-06mmHg at 25°C
Boiling Point:383°C at 760 mmHg
Flash Point:185.4°C
Density:1.142g/cm³
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:312.13953042
Heavy Atom Count:21
Complexity:323

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(CO1)CCCCCCOCC2=CC=CS2

Technology Process of Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate

There total 8 articles about Ethyl (2R)-2-(6-(thienylmethoxy)hexyl)oxirane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201734-41-0
2-hydroxy-8-(thiophen-2-ylmethoxy)-2-(toluene-4-sulfonyloxymethyl)-octanoic acid ethyl ester

: 327969-65-3
ethyl 2-[6-(2-thiophenemethoxy)hexyl]oxirane-2-carboxylate

Guidance literature:: With potassium carbonate; In ethanol; at 20 ℃; for 6h;
DOI:10.3987/COM-98-8235

Reference yield:

: 629-11-8
1,6-hexanediol

: 327969-65-3
ethyl 2-[6-(2-thiophenemethoxy)hexyl]oxirane-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / triethylamine / tetrahydrofuran / 1.5 h / 20 °C

2: 77 percent / NaH / tetrahydrofuran / 16 h / 20 °C

3: 89 percent / NaH / tetrahydrofuran / 16 h / Heating

4: 79 percent / potassium hydroxide / ethanol / 6 h / 20 °C

5: 83 percent / Eschenmosher's salt; NaH / tetrahydrofuran / 16 h / Heating

6: 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 1.5 h / 20 °C

7: pyridine / 3 h / 0 °C

8: K₂CO₃ / ethanol / 6 h / 20 °C

With pyridine; potassium hydroxide; osmium(VIII) oxide; eschenmoser's salt; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; ethanol; water; acetone; tert-butyl alcohol; 1: Alkylation / 2: Etherification / 3: Alkylation / 4: Hydrolysis / 5: Reduction / 6: hydroxylation / 7: Tosylation / 8: Cyclization;
DOI:10.3987/COM-98-8235

Reference yield:

: 4239-24-1
1,6-hexanediol dimethanesulfonate

: 327969-65-3
ethyl 2-[6-(2-thiophenemethoxy)hexyl]oxirane-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / NaH / tetrahydrofuran / 16 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran / 16 h / Heating

3: 79 percent / potassium hydroxide / ethanol / 6 h / 20 °C

4: 83 percent / Eschenmosher's salt; NaH / tetrahydrofuran / 16 h / Heating

5: 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 1.5 h / 20 °C

6: pyridine / 3 h / 0 °C

7: K₂CO₃ / ethanol / 6 h / 20 °C

With pyridine; potassium hydroxide; osmium(VIII) oxide; eschenmoser's salt; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; ethanol; water; acetone; tert-butyl alcohol; 1: Etherification / 2: Alkylation / 3: Hydrolysis / 4: Reduction / 5: hydroxylation / 6: Tosylation / 7: Cyclization;
DOI:10.3987/COM-98-8235