3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

Base Information

Chemical Name:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile
CAS No.:152120-04-2
Molecular Formula:C₃₃H₃₂FNO₃
Molecular Weight:509.62
Hs Code.:

Synonyms:3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

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Chemical Property of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

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Technology Process of 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

There total 5 articles about 3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 59577-13-8
3-(2-hydroxyphenyl)propanenitrile

: 152120-07-5
2-benzyloxy-1-(4-fluorophenyl)-5-ethyl-4-(3-chloro-1-propyloxy)benzene

: 152120-04-2
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152120-04-2
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 56 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrachloromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 152609-59-1
1-benzyloxy-4-ethyl-3-(3-chloro-1-propyloxy)-benzene

: 152120-04-2
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

2: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

3: 56 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00022a006