[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

Base Information

Chemical Name:[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine
CAS No.:87306-96-5
Molecular Formula:C₂₃H₃₂BrNO₂Si
Molecular Weight:462.502
Hs Code.:

Synonyms:[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

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Chemical Property of [1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

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Technology Process of [1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

There total 4 articles about [1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87306-92-1
C₂₃H₃₃BrClNO₂Si

: 87306-96-5
[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

Guidance literature:: With 18-crown-6 ether; In diethyl ether; Ambient temperature;
DOI:10.1021/jo00170a036

Reference yield:

: 87306-78-3
(1R,2R)-2-(2-Bromo-benzylamino)-3-methoxy-1-phenyl-propan-1-ol

: 87306-96-5
[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / tetrahydrofuran / 12 h / Ambient temperature

2: NCS / CH₂Cl₂ / 0.25 h

3: KO₂, 18-crown-6 / diethyl ether / Ambient temperature

With 1H-imidazole; N-chloro-succinimide; 18-crown-6 ether; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00170a036

Reference yield:

: 77250-60-3
(4S,5S)-2-(2-bromophenyl)-4-methoxymethyl-5-phenyl-2-oxazine

: 87306-96-5
[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DIBAL / diethyl ether / 18 h / Ambient temperature

2: 94 percent / imidazole / tetrahydrofuran / 12 h / Ambient temperature

3: NCS / CH₂Cl₂ / 0.25 h

4: KO₂, 18-crown-6 / diethyl ether / Ambient temperature

With 1H-imidazole; N-chloro-succinimide; 18-crown-6 ether; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00170a036