dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

Base Information

Chemical Name:dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate
CAS No.:1616874-56-6
Molecular Formula:C₂₀H₂₆NO₃P
Molecular Weight:359.405
Hs Code.:

Synonyms:dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

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Chemical Property of dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

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Technology Process of dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

There total 5 articles about dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1616874-15-7
dimethyl (2-(cyclopropylethynyl)cyclohex-1-enyl)-(phenylamino)methylphosphonate

: 1616874-56-6
dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

Guidance literature:: With gold(III) tribromide; potassium tert-butylate; In chloroform; at 20 ℃; regioselective reaction;
DOI:10.1021/jo501011u

Reference yield:

: 1330631-53-2
2-(2-cyclopropylethynyl)-1-cyclohexenecarboxaldehyde

: 1616874-56-6
dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 20 °C

2: potassium tert-butylate; gold(III) tribromide / chloroform / 20 °C

With gold(III) tribromide; boron trifluoride diethyl etherate; potassium tert-butylate; In dichloromethane; chloroform; 1: |Kabachnik-Fields Reaction;
DOI:10.1021/jo501011u

Reference yield:

: 62-53-3
aniline

: 1616874-56-6
dimethyl 3-(cyclopropylmethyl)-2-phenyl-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 20 °C

2: potassium tert-butylate; gold(III) tribromide / chloroform / 20 °C

With gold(III) tribromide; boron trifluoride diethyl etherate; potassium tert-butylate; In dichloromethane; chloroform; 1: |Kabachnik-Fields Reaction;
DOI:10.1021/jo501011u