methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate

Base Information

• Chemical Name: methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate
• CAS No.: 188050-48-8
• Molecular Formula: C₂₃H₂₅N₃O₄S
• Molecular Weight: 439.535

Synonyms:methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate

Chemical Property of methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate

Chemical Property:

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Technology Process of methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate

There total 5 articles about methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ^4,α-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) + 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]-4-piperidone (188050-46-6) → methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ4,α-acetate (188050-48-8)

Guidance literature:

In benzene; for 7h; Heating;

DOI:10.3987/COM-96-7605

Reference yield:

3-(2-bromoethyl)-7-azaindole (90929-75-2) → methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ4,α-acetate (188050-48-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / sodium hydrogencarbonate / acetonitrile / 4 h / Heating

2: 94 percent / BuLi / tetrahydrofuran; cyclohexane / 3 h / Ambient temperature

3: 45 percent / 6N HCl / acetone / 6 h / Heating

4: 39 percent / benzene / 7 h / Heating

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; cyclohexane; acetone; acetonitrile; benzene;

DOI:10.3987/COM-96-7605

Reference yield:

4,4-ethylenedioxy-piperidine (177-11-7) → methyl 1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]piperidine-Δ4,α-acetate (188050-48-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / sodium hydrogencarbonate / acetonitrile / 4 h / Heating

2: 94 percent / BuLi / tetrahydrofuran; cyclohexane / 3 h / Ambient temperature

3: 45 percent / 6N HCl / acetone / 6 h / Heating

4: 39 percent / benzene / 7 h / Heating

With hydrogenchloride; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; cyclohexane; acetone; acetonitrile; benzene;

DOI:10.3987/COM-96-7605

upstream raw materials:

methyl (triphenylphosphoranylidene)acetate

1-[2-(1-phenylsulfonylpyrrolo[2,3-b]pyridin-3-yl)ethyl]-4-piperidone

3-(2-bromoethyl)-7-azaindole

4,4-ethylenedioxy-piperidine

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