(S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester

Base Information

• Chemical Name: (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester
• CAS No.: 161813-74-7
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Mol file: 161813-74-7.mol

Synonyms:(S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester

Chemical Property of (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester

There total 10 articles about (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl 2-ethyl(2S)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate (191851-81-7) → (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester (161813-74-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 18h;

DOI:10.1021/jo00097a022

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 3,4-dehydro-L-proline (4043-88-3,58640-72-5) → (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester (161813-74-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

N-Cbz-trans-4-methylxanthate-L-proline (1426534-95-3) → (S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-benzyl ester (161813-74-7)

Guidance literature:

With sodium carbonate; In ethanol; water; Microwave irradiation;

upstream raw materials:

1-benzyl 2-ethyl(2S)-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate

(R)-4-hydroxy-L-proline ethyl ester

methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

1-benzyl 2-ethyl(2S,4S)-4-(phenylselanyl)pyrrolidine-1,2-dicarboxylate

Downstream raw materials:

(1S,2S,5R)-6-oxa-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid dibenzyl ester

(1R,2S,5S)-6-oxa-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid dibenzyl ester

(2S,3R,4R)-3-hydroxy-4-methoxy-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester

(S)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid dibenzyl ester