(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

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Chemical Name:(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
CAS No.:1196552-18-7
Molecular Formula:C₂₆H₂₀F₂N₆
Molecular Weight:454.482
Hs Code.:

Synonyms:(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

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Chemical Property of (R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

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Technology Process of (R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

There total 3 articles about (R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196552-07-4
(R)-3-(6-bromopyridin-2-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1196552-18-7
(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: With water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 110 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1196548-56-7
(R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

: 1196552-18-7
(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 20 h / 120 °C

2: phosphorus tribromide / 0.58 h / 175 °C

3: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

With water; phosphorus tribromide; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane;

Reference yield:

: 1196552-17-6
(R)-6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-ol

: 1196552-18-7
(R)-3-(2'-fluoro-2,4'-bipyridin-6-yl)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / 0.58 h / 175 °C

2: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

With water; phosphorus tribromide; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane;