1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide)

Base Information

• Chemical Name: 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide)
• CAS No.: 269054-83-3
• Molecular Formula: C₄₅H₅₄N₆O₉
• Molecular Weight: 822.959
• Mol file: 269054-83-3.mol

Synonyms:1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide)

Chemical Property of 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide)

There total 3 articles about 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,3,5-benzene tris(carbonyl chloride) (4422-95-1) + tert-butyl (4-aminobenzyl)carbamate (94838-55-8) → 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide) (269054-83-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

DOI:10.1021/ja992648l

Reference yield:

(4-aminomethyl)aniline (4403-71-8) → 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide) (269054-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Et₃N / acetone / 0.5 h / 20 °C

2: 82 percent / DIEA / CH₂Cl₂ / 2 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/ja992648l

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1,3,5-benzene tris(N-(tert-butyloxycarbonyl)-4'-aminomethylphenyl carboxamide) (269054-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Et₃N / acetone / 0.5 h / 20 °C

2: 82 percent / DIEA / CH₂Cl₂ / 2 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/ja992648l

upstream raw materials:

1,3,5-benzene tris(carbonyl chloride)

tert-butyl (4-aminobenzyl)carbamate

di-tert-butyl dicarbonate

(4-aminomethyl)aniline