Technology Process of methyl 5-({[9-(3-fluorobenzyl)-5,6,8,9-tetrahydro-7H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridin-7-yl]carbonyl}amino)-2,2-dimethylpentanoate
There total 4 articles about methyl 5-({[9-(3-fluorobenzyl)-5,6,8,9-tetrahydro-7H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridin-7-yl]carbonyl}amino)-2,2-dimethylpentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-methoxy-5,5-dimethyl-6-oxohexanoic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 120 ℃;
for 2h;
9-(3-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrido[4',3':4,5]pyrrolo[2,3-b]pyridine dihydrochloride;
With
pyridine;
In
dichloromethane; toluene;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 1.83 h / -68 - -64 °C
1.2: -62 °C
2.1: hydrogen; palladium 10% on activated carbon; hydrogenchloride / 1,4-dioxane; methanol / 3.5 h / 50 °C
3.1: sodium periodate; rhodium(III) chloride hydrate / water; tetrachloromethane; acetonitrile / 4.05 h / 20 °C
4.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 120 °C
4.2: 1 h / 20 °C
With
hydrogenchloride; sodium periodate; rhodium(III) chloride hydrate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; n-heptane; ethylbenzene; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen; palladium 10% on activated carbon; hydrogenchloride / 1,4-dioxane; methanol / 3.5 h / 50 °C
2.1: sodium periodate; rhodium(III) chloride hydrate / water; tetrachloromethane; acetonitrile / 4.05 h / 20 °C
3.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 120 °C
3.2: 1 h / 20 °C
With
hydrogenchloride; sodium periodate; rhodium(III) chloride hydrate; diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine;
In
1,4-dioxane; methanol; tetrachloromethane; water; toluene; acetonitrile;
