(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

Base Information

Chemical Name:(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane
CAS No.:1395922-48-1
Molecular Formula:C₁₉H₂₁BrO₆
Molecular Weight:425.276
Hs Code.:

Synonyms:(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

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Chemical Property of (2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

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Technology Process of (2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

There total 1 articles about (2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (2R)-2-(4'-bromo-2'-hydroxy-6'-methoxyphenoxy)-1-(3',4',5'-trimethoxyphenyl)propan-1-ol

: 1395922-48-1
(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

: 1395922-55-0
(2S,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

Guidance literature:: With Amberlyst 15; In toluene; for 21h; Inert atmosphere; Reflux;
DOI:10.1021/jo3015006

Reference yield: 73.0%

: 1395922-48-1
(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1395922-49-2
(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-5-methoxy-1,4-benzodioxane

: (-)-eusiderin L

Guidance literature:: (2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water;
DOI:10.1021/jo3015006

Reference yield:

: 1395922-48-1
(2R,3R)-3-methyl-2-(3',4',5'-trimethoxyphenyl)-7-bromo-5-methoxy-1,4-benzodioxane

: 1400817-53-9
(-)-eusiderin G

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: toluene / 72 h / Inert atmosphere; Reflux

With tert.-butyl lithium; In tetrahydrofuran; toluene; 2.1: |Wittig Olefination;
DOI:10.1021/jo3015006