4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Base Information

Chemical Name:4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine
CAS No.:136859-67-1
Molecular Formula:C₄₇H₄₇ClN₄O₄Si
Molecular Weight:795.453
Hs Code.:

4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Synonyms:4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

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Chemical Property of 4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

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Technology Process of 4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

There total 2 articles about 4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 136859-65-9
2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 14470-28-1
mono-4-methoxytrityl chloride

: 136859-67-1
4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; for 3h; Ambient temperature;
DOI:10.1002/hlca.19910740517

Reference yield:

: 123439-70-3
2-amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 136859-67-1
4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) CrO₃-pyridine-Ac₂O; 2) NaBH₄ / 1) CH₂Cl₂, room temp.; 2) EtOH, 0 deg C, 2 h

2: 94 percent / (i-Pr)2EtN / pyridine / 3 h / Ambient temperature

With sodium tetrahydroborate; CrO₃*pyridine*acetic anhydride; N-ethyl-N,N-diisopropylamine; In pyridine;
DOI:10.1002/hlca.19910740517

Reference yield: 29.0%

: 136859-67-1
4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

: 136859-68-2
4-Chloro-7-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-3-fluoro-β-D-erythro-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With diethylamino-sulfur trifluoride; In pyridine; dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1002/hlca.19910740517