8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate

Base Information Edit

Chemical Name:8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate
CAS No.:1259040-07-7
Molecular Formula:C₂₃H₃₄N₂O₄
Molecular Weight:402.534
Hs Code.:
Mol file:1259040-07-7.mol

Synonyms:8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate

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Chemical Property of 8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate Edit

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Technology Process of 8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate

There total 2 articles about 8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate: 135716-08-4
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

: 1259040-07-7
8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; toluene; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0036-1588902

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1259040-07-7
8-(tert-butyl) 4-ethyl 2-benzyl-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: trifluoroacetic acid / toluene / 40 h / Inert atmosphere

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; toluene;