(S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid

Base Information

• Chemical Name: (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid
• CAS No.: 1455092-62-2
• Molecular Formula: C₂₆H₂₆N₄O₇
• Molecular Weight: 506.515
• Mol file: 1455092-62-2.mol

Synonyms:(S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid

Chemical Property of (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid

There total 2 articles about (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester (1455091-23-2) + (2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid (25691-37-6,80445-78-9) → (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid (1455092-62-2)

Guidance literature:

With sodium methylate; In 2-methoxy-ethanol; for 3h; Reflux;

Reference yield:

Nα-t-Boc-Nγ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid (117106-21-5,131570-57-5) → (S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid (1455092-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: sodium methylate / 2-methoxy-ethanol / 3 h / Reflux

With piperidine; sodium methylate; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

(S)-2-(tert-butoxycarbonylamino)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid (1455092-62-2) + trifluoroacetic acid (76-05-1) → (S)-2-amino-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid TFA salt (1455087-84-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

N^α-t-Boc-N^γ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid

1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

(2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid

Downstream raw materials:

(S)-2-amino-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)butanoic acid TFA salt