C₄₁H₃₂F₃N₅O₂

Base Information

• Chemical Name: C₄₁H₃₂F₃N₅O₂
• CAS No.: 1222999-54-3
• Molecular Formula: C₄₁H₃₂F₃N₅O₂
• Molecular Weight: 683.733
• Mol file: 1222999-54-3.mol

Synonyms:C₄₁H₃₂F₃N₅O₂

Chemical Property of C₄₁H₃₂F₃N₅O₂

Chemical Property:

Purity/Quality:

N-(1-Methylpiperidin-4-yl)-4'-(2-oxo-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₃₂F₃N₅O₂

There total 12 articles about C₄₁H₃₂F₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

C32H26ClF3N4O2 (1314568-36-9) + quinolin-3-ylboronic acid (191162-39-7) → C41H32F3N5O2 (1222999-54-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1016/j.bmcl.2011.04.129

Reference yield:

4-Amino-1-methylpiperidine (41838-46-4) → C41H32F3N5O2 (1222999-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane / 2 h / 80 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos / 1,4-dioxane / 4 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; 2: Suzuki coupling / 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.04.129

Reference yield:

N-(1-methylpiperidin-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (879486-51-8) → C41H32F3N5O2 (1222999-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane / 2 h / 80 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos / 1,4-dioxane / 4 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; tert-butyl XPhos; In 1,4-dioxane; 1: Suzuki coupling / 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.04.129

upstream raw materials:

4-Amino-1-methylpiperidine

N-(1-methylpiperidin-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

C₃₂H₂₆ClF₃N₄O₂

quinolin-3-ylboronic acid

Refernces

• 1、 -. "SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF". Page/Page column 124. . Retrieved 2010/04/30.