Synonyms:DTXSID70929193;F4443374-BFD1-4FE5-9B7E-27B5ED4E590D
99% *data from raw suppliers
The research focuses on the development of a broad and efficient protocol for the cross-coupling reactions of alkali-metal arylsilanolate salts with aromatic and heteroaromatic bromides and chlorides, leading to the formation of polysubstituted biaryls. The purpose of this study was to expand the substrate scope and improve the efficiency of cross-coupling reactions beyond the limitations of traditional boron- or tin-based reagents, which can be problematic in certain cases. The researchers successfully demonstrated that a wide range of electron-rich, electron-poor, and sterically hindered aryldimethylsilanolates could undergo smooth coupling with a variety of aryl halides under catalysis by (t-Bu3P)2Pd. The use of preformed silanolate salts offered several advantages, including ease of synthesis, stability, resistance to disiloxane formation, and self-activating properties. The study concluded that this method is particularly advantageous for cases where traditional reagents are not suitable and has broad potential for adoption in the synthesis of complex molecules. Key chemicals used in the process include arylsilanols, arylsilanolates, aromatic and heteroaromatic halides, and the palladium catalyst (t-Bu3P)2Pd.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
